Optimum Waveforms for Differential Ion Mobility Spectrometry (FAIMS)

Resolution enhancement of field asymmetric waveform ion mobility spectrometry (FAIMS) by ion focusing

BACKGROUND Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) is a material analysis technology which develops very fast in recent years. Resolution is an important factor used to estimate the performance of this technology. With greater resolution, it's always easier to separate complex mixtures. RESULTS A method to increase the resolution of FAIMS is put forward which focuses ions ...

Ion Mobility Mass Spectrometry

for more complex analysers for automated sample processing and plant control. The separation time will continue to decrease; in the past there has been limited interest in fast separations but this could change as automated sample processing is developed. Increasing use of coupled techniques such as GC-GC, liquid chromatography-GC, and supercritical Suid chromatography-GC for the separation of ...

Ion Mobility-Mass Spectrometry

Protein analyses using differential ion mobility microchips with mass spectrometry.

Differential ion mobility spectrometry (FAIMS) integrated with mass spectrometry (MS) is a powerful new tool for biological and environmental analyses. Large proteins occupy regions of FAIMS spectra distinct from peptides, lipids, or other medium-size biomolecules, likely because strong electric fields align huge dipoles common to macroions. Here we confirm this phenomenon in separations of pro...

Application of Ion Mobility Spectrometry for Determination of Morphine in Human Urine

In this study, a rapid, simple and sensitive ion mobility spectrometry (IMS) method with corona discharge as ionization source was described for the morphine determination in human urine. Morphine was extracted and purified from urine samples using solid phase extraction procedure with C18 column. It can offer the clean extracts which no extra peaks were observed in IMS. Under operating experim...